Olaf Gorter and Tiago Gabriel struck in the second half as Lecce secured a clinical 2-0 victory over Venezia at Stadio Pier Luigi Penzo.
The visitors weathered heavy periods of pressure in the opening round of Serie A before punishing their hosts immediately after the interval.
Gorter broke the deadlock in the 46th minute, finishing sharply within seconds of the restart to give the away side the advantage.
Venezia dominated possession across the ninety minutes and pushed relentlessly for an equaliser, registering 19 attempts on goal.
Antoine Hainaut forced a sharp save as the home side pressed forward, but the hosts were repeatedly denied in the final third.
Lecce goalkeeper Wladimiro Falcone produced six vital saves on the evening, frustrating the home attack and preserving his clean sheet.
Venezia manager Eusebio Di Francesco introduced Nikola Stulic in the 74th minute in search of a late attacking breakthrough.
Lecce countered by bringing on Gabriel, who made an immediate impact off the bench to put the contest out of reach.
Gabriel sealed the three points with ten minutes remaining, slotting home in the 80th minute to double the visitors' lead.
The result leaves Venezia empty-handed despite controlling 71% possession, while Lecce start their league campaign with maximum points.
